Instrumentation and setup
Dynatrace OneAgent installs once and auto-discovers everything on the host. It's the fastest 'install to insight' in the industry.
New Relic has an installer wizard and language-specific agents. Setup is quick but less automatic than Dynatrace.
Both support OpenTelemetry alongside their proprietary agents.
If you want zero-config observability, Dynatrace wins. If you prefer explicit control, New Relic feels less magical.